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Ongoing Activities - Research Lines

Currently ongoing: the Gambling project (2013-2014 track its goals and progress). Follow our older activities through: the CHART OF EXPERIMENTS of the (closed) ADHD-sythe project (2009-2012); the LIST OF DELIVERABLES of the active NeuroGenMRI project (2011-2014).

 
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BROWSE through our ongoing (active) research projects. Jump to first one and then come back to the latest > use "prev" OR "next" buttons at the footer of each page
 
Innocent WAR PLAN 2017 | very old experiments!
 
 2014-17 Leo et al. : first announcement about improvement of ADHD models by the DAT knockout rat. Under revision.
 2014-17 Famele et al. : announcement about we have been the first to measure nicotine transfer mother to pup via milking. Under revision.
 2014-17 Faure et al. : behaviour sequelae of nicotine exposure (drinking mother to lactating pups). Writing manuscript.
 2014-17 Tistarelli et al. : MR connectivity in developing brains during juvenile to adolescent phases. Writing manuscript.
 2014-17 Paizanis et al. : behavioural phenotype of rats inoculated with lenti--SERT in the hippocampus. Assembling data.
 2014-17  (Glennon / Homberg) : ex vivo measures in brains of NHE rats, an animal model of ADHD. Organising assays.
 
 
 (since 2008) Screening of behavior in the home cage : development of an operant panel for motivated decisions (see contents under Section: Areas Covered). This new home cage panel is available. Have a look to our partner (the small company PRS ITALIA) follow our products ; further validation studies are now run, under the Gambling project (2013-2014 track its goals and progress), aimed to validate innovative animal models for pathological gambling and proneness to risky choices. 

 

 (since 2008) Development of a novel non-psychostimulant drug to treat depression, anxiety, and ADHD in children. One new targets is the Serotonin 7 (5-HT7) receptor (see content under Section: Areas Covered). Following abstract to the Bioactive Peptides 2008 congress, Napoli, IT, one paper has been published (Adriani et al., ONPPJ 2009) on cortexin, a Russian medication to ADHD. Further experiments were run under "ADHD-sythe" (2009-2012 see achieved goals), and are now planned under "NeuroGenMRI" (2011-2014 track the progresses). Main aims are a) selection of novel possible receptor targets, b) development of new psychoactive compounds (molecules/peptides), and c) preclinical evaluation of their behavioral and neuro-pharmacological effects.

 


 (since 2006) Modulation of behavior by anti-neural auto-antibodies (aAbs) generated by immunization with fragments of neuro-receptors.  The paper we published first, Capone et al., Psycho-pharmacology 2008, describes interaction of anti-Mu receptor aAbs on morphine's effects in mice. Another paper about anti-DAT aAbs (generated by DAT-fragment immunization), and consequent changes in behavior and brain neurochemical parameters, is currently published (Adriani et al., Behavioral and Brain Functions 2012) and is available for free download !!! On the same line, a paper (Koot et al., Behavioral Brain Research 2008 available for free download) describes the latest refinement for running operant tasks for behavioral impulsivity in mice.    

 (since 2006) Development and validation of a novel diagnostic kit. This has been also run under ADHD-sythe, aimed to exploit a potential new biomarker in human ADHD (check the goals achieved 2009-2012) and is now partialy run under NeuroGenMRI (2011-2014 track the "clinical" progresses). 


 (since 2004) Modulation of behavior by gene transfer into the brain : inoculation of tools (lentiviruses) carrying gene enahncers or silencers. In line with the abstract presented to the FENS 2008 (Geneva, CH), two pioneer papers (Adriani et al., Neuroscience 2009 available for free download ; Adriani et al., Int J NeuroPsychoPharmacol 2010) should be disseminated. This Activity was run under the ADHD-sythe project (2009-2012 see achieved goals), and is now run under the NeuroGenMRI project (2011-2014 track), aimed to validate innovative animal models for ADHD and adolescent depression. Novel basic knowledge on neurobiology of neuropsychiatric disorders will improve therapy !!!

 (since 2004) Magnetic resonance and the brain: pharmacological imaging of areas activated by psychoactive drugs. Abstract presented to the BCN-ISS congress, Roma 2007, and to the Translational Medicine congress held at ISS, Roma 2008. One pilot paper (Canese et al., Psycho-pharmacology 2008 download for free) describes MPH-induced BOLD effect in brains of adolescent and adult rats (studied with in vivo ph-MRI). This Activity was run under "ADHD-sythe" (2009-2012 see achieved goals), and is now run under "NeuroGenMRI" (2011-2014  track the progresses): we aim to perform magnetic resonance (MR) measures in brains of both ADHD childrens and animal models, to draw possible useful correlations...   


(closed) Neuroprotection for drug abuse-induced toxicity and in neuro-degenerative diseases (in collaboration with Sigma Tau SpA, Pomezia, Italy).  

(closed) Behavioural effects of novel drugs modulating the endocannabinoid system (in collaboration with Sigma Tau SpA, Italy).  Papers already published are available on our site.

The announcement of congresses is available on our website (see column on the right).

On the  "publications" page  you will find papers originated from activities of past years. 

 
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Events and Links

Meetings & Congresses

 Index of Congresses ...

 Forthcoming-


the 13th Dresden Symposium on Autoantibodies in September 2017.

 



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Debates & Lessons
    
Beyond science: philosophy, mind and metabolism:
 
1) Genes, but ...NOT ONLY...

2) Latest hints on innovation: "ALTERNATIVE MEDICINES"

3) The burden of ADHD on modern society (families, health systems).
 
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Societies, Journals (to visit)

Science Societies, Science Journals.

Associations to help people with a psychiatric disease (and their families).
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