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News on Neurodevelopmental Disorders & Addiction


Animal research is brave, not cruel, science! Sign! 

EMMA is committed to divulge and to highlight discoveries on new therapeutic tools for disease of mind & metabolism (e.g., depression, mood disorders, psychoses, mental retardation, etc.) - BROWSE the section using "Prev" and "Next" buttons at footer of pages.

Posted on: 20 Apr 2015

Risultati immagini per gambling addiction animal model

          Animal models in gambling research: search the jackpot…


          At a recent meeting in Nantes on behavioural addictions, Ruud van den Bos gave a presentation on animal models in gambling research.

This column posted on FrontiersIn reflects his lecture along with some after thoughts.


Disordered gambling is a major societal problem with high costs to the subjects involved. Animal models may help in understanding and preventing gambling-related problems. Data show that some (lab) animals may have a gambling-like profile, yet we need additional steps to come to models of disordered gambling. Read all


Rats switch to random mode when up against hard-to-beat competitors, and we should too


Laboratory rats can flip their little rodent brains from strategic predictable decisions to random choices and if they can do that scientists say we too can embrace the joys and the reduced pressure of random decision-making. The brain is designed to make decisions based on experience. But it can also make us predictable or even biased.

Maybe it doesn't have to be this way. A new study on rats, published in the journal Cell, shows their brains can apparently act randomly when facing difficult competitors. And some believe humans should also embrace the power of randomness for small and even large life choices.



Oxytocin promotes group-serving dishonesty, by Shaul Shalvi and Carsten K.W. De Dreu : Full Text or PDF

Significance: Very little is known about the biological foundations of immoral behavior ... These findings support the functional approach to morality and reveal the underlying biological circuitries associated with group-serving dishonesty.


New Schizophrenia Warning Sign & Link with Fragile X Syndrome  

 Read discoveries on " Schizophrenia and Mental Retardation , unespected links ".
 The later you start trying/taking drugs, the easiest to quit.
  Adolescence appears to be a period of heightened propensity to develop addictions but the biological factors that increased vulnerability were not known. New research carried out in rats and published in the Journal of Neuroscience provides important clues. Relative to adults, adolescent rats took cocaine more readily, were more sensitive to lower doses, showed greater escalation of cocaine intake, and were less susceptible to increases in work they had to do to get the drug.

 Adolescent rats also showed increased activity of dopamine neurons, a feature known to be associated with increased drug self-administration behaviour. Dopamine is essential or drug-induced reward. The results highlight behavioural and biological markers of heightened addiction liability during adolescence

Wong et al. (2013) Adolescents Are More Vulnerable to Cocaine Addiction: Behavioral and Electrophysiological Evidence. The Journal of Neuroscience, 33: 4913-4922

Anselme P (2010 - link to DOI). The uncertainty processing theory of motivation. Behav Brain Res. 208: 291-310. Epub 2009 Dec 23.

Paper just published in Neuroscience & Neuroeconomics about economic decision making - attractive effects of immediate reward and reward-cues (i.e., TEMPTATION) GO & READ

A Neuroeconomic Theory of Bidirectional Synaptic Plasticity and Addiction (2010) Med Hypotheses, 75: 356-358

Taiki Takahashi 

proposes, in
this paper, a possible link between economic theory of addiction (Becker and Murphy, 1988) and neurobiological theory of bidirectional synaptic plasticity (Bienenstock, Cooper, Munro, 1982).

Evaluation of animal models of neuro-behavioral disorders. By van der Staay FJ, Arndt SS, Nordquist RE. Behav Brain Funct. 2009 ; 5:11.

Click here to read Click here to read

The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations ...

Click here to read

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