European Mind & Metabolism Association

Users' LogIn :
  LOGIN FORM !

support & sponsors welcomed


Donate !!! How ?
  Do go & click here !
You are here: Home
  • Decrease font size
  • Default font size
  • Increase font size
Schizophrenia, Mental Retardation

Researchers Uncover New Schizophrenia Warning Sign and Discover Link with Fragile X Syndrome

Nelson Freimer, M.D., expert on schizophrenia research
Nelson Freimer, M.D.
An international team of researchers, including NARSAD Grantee, Nelson Freimer, M.D., from the University of California at Los Angeles (UCLA) has made two discoveries related to schizophrenia. First, they found a rare gene mutation that increases a person’s susceptibility to developing schizophrenia. Second, they uncovered a previously unknown link between schizophrenia and Fragile X syndrome. The results of this work were published August 4th in the online edition of Nature Neuroscience.
Focusing their research on a unique population in northeastern Finland, a community that has lived in relative isolation for hundreds of years, the scientists were able to sift through genomic data for mutations or inconsistencies. This population has three times the frequency of schizophrenia compared to the rest of Finland and a higher rate of intellectual impairment. They found a rare genetic deletion affecting a gene known as TOP3B that increases a person’s likelihood of developing schizophrenia. The next step was trying to understand why this genetic deletion had this profound effect. They discovered that the protein encoded by TOP3B interacts with another protein called FMRP. Past research has shown that the disruption of FMRP is responsible for Fragile X syndrome, which is the most commonly known genetic cause of autism.
"What is interesting about this study is that through investigations in an isolated corner of Finland, we are contributing to concerted international efforts that are beginning to unravel the genetic root of schizophrenia, a debilitating disorder that affects so many people throughout the world,” explains Dr. Freimer. “Potentially, this may someday lead to new drug targets against these disorders."
 
 
< Prev   Next >
 

How many online?

We have 1 guest online

Events and Links

Meetings & Congresses

 Index of Congresses ...

 Forthcoming-


the 13th Dresden Symposium on Autoantibodies in September 2017

 



Read more...
 
Debates & Lessons
 User Access:  LOGIN
 
    
Beyond science: philosophy, mind and metabolism:
 
1) Genes, but ...NOT ONLY...

2) Latest hints on innovation: "ALTERNATIVE MEDICINES"

3) The burden of ADHD on modern society (families, health systems).
 
Read more...
 
Societies, Journals (to visit)

Science Societies, Science Journals.

Associations to help people with a psychiatric disease (and their families).
Read more...
 

Sondage

Which of these lotteries would you bet a stake on?